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Guotai Junan's annual strategy for innovative drugs in 2025: innovative pharmaceutical companies have accelerated into the harvest period, and the valuation has been at a historical low in the past five years. Guotai Junan said that the centralized purchasing policy has become stable, mature and normalized, and the marginal impact has weakened. Innovative drugs have gained policy inclination in the medical insurance negotiation. In the past two years, the policy has continued to promote pharmaceutical innovation, and the top-level design and local supporting chain support the development of innovative drugs. Commercial insurance is expected to bring new growth momentum to China's pharmaceutical market, and the overall industry trend is upward. At present, the trend of innovative drug industry is improving, the supply continues to accelerate, and a number of domestic innovative drugs are approved soon, which is expected to drive a new round of heavy volume. At the same time, the commercialization has achieved remarkable results and has occupied a dominant position in some sub-sectors. Pharma's performance continued to differentiate, and innovative drugs and just-needed drugs performed well. Biotech commercialization continues to increase, per capita yield continues to increase, the node of turning losses is approaching, and innovation ushers in the harvest period. Horizontal comparison: compared with overseas peers, the overall valuation of domestic innovative pharmaceutical companies is in a historically low range; Vertical comparison: the valuation of SW- pharmaceutical biology and SW- chemical preparations is at a historical low in the past five years, and it is expected that the valuation of subsequent sectors will pick up.Details of the life of the murder suspect of UnitedHealth Insurance Company surfaced. On Tuesday, Luigi Mangione, the suspect accused of shooting a senior executive of United Health, had a brief struggle with police officers and shouted angrily when he was taken to a court in Pennsylvania. Man Ghioni, 26, turned to a group of reporters and shouted, "... completely unsociable, insulting the wisdom of the American people!" And then pushed away by the police. It is not clear what he is referring to. On Tuesday, more clues about his possible motive gradually surfaced. According to the police, Man Ghione had a handwritten declaration when he was arrested, which can let people know his mentality. According to The New York Times, an internal report of the new york police, after analyzing the document, concluded that Man Ghioni believed that killing was a proper response to what he thought was corruption in the medical industry. It is reported that Mann Ghioni wrote in the manifesto: "These parasites deserve it". According to Mancini's friends, his social media posts and other news reports, Mancini suffers from chronic back pain, which limits his daily life. His profile on X-ray shows an X-ray background picture with screws and steel plates inserted into his lower back.A new generation of quantum chips has achieved a breakthrough in error correction capability. According to a paper published in Nature magazine on the 10th, Google's latest generation of quantum chips has achieved a breakthrough in error correction capability, that is, the error is suppressed below a critical threshold. This quantum error correction function is considered as a necessary condition to realize the practical application of quantum computing in the future. After the performance of the chip is expanded, it may be able to promote the operation requirements of large-scale fault-tolerant quantum computing.

Citic Jiantou: The demand for promoting the release of opinions on the pipeline network and water renovation in resilient cities is expected to increase. According to the research report of CITIC Jiantou, recently, the general offices of the General Office of the Central Committee of the CPC and the State Council issued the Opinions on Promoting the Construction of New Urban Infrastructure to Create a Resilient City, which clearly stated that it is necessary to build an intelligent and efficient new urban infrastructure system and continuously improve the resilience of urban facilities, management and space. Specifically, the Opinions propose that by 2027, the construction of new urban infrastructure will make significant progress, and the supporting role for the construction of resilient cities will be continuously enhanced, forming a number of experiences and practices that can be replicated and promoted. In addition, the Opinions also proposes the implementation of intelligent municipal infrastructure construction and transformation, and the digital transformation and upgrading and intelligent management of urban water supply, drainage, power supply, gas, heat, fire hydrants (fire cranes), underground utility tunnel and other municipal infrastructure according to local conditions. We believe that in the process of building a resilient city, the demand for urban infrastructure renewal and construction is expected to continue to grow, and related water and sanitation equipment enterprises are expected to benefit.Maotai Group went to Laos, Cambodia and Thailand for investigation and exchange. From December 3 to 9, local time, Wan Bo, member of the Party Committee and deputy general manager of Maotai Group, led a team to Laos, Cambodia and Thailand for investigation and exchange. Through in-depth investigation of the local market, the brand promotion activities of "Maotai Night" were carried out, which continued to promote Maotai's deep cultivation in Southeast Asia. During this period, Wanbo and his party also visited Eisenwo, Chairman of the China-Cambodia Friendship Exchange Association, Princess Norodom Allen Rasmi, Director of the Cambodian Royal Modita Foundation, former Thai Deputy Prime Minister Chichai Vanashati, Chairman of the Thailand-China Friendship Association and former Thai Deputy Prime Minister Gong Taparansi, and Lao Minister of Education and Sports Pu Simarong to discuss how Maotai culture and Southeast Asian cultures can be blended and promoted together to help Maotai and China traditional culture go to sea.CITIC Jiantou: China's commercial space layout continues to land, and SpaceX's first mobile phone direct connection constellation has been built. CITIC Jiantou Research Report said that China's state-owned private enterprises have laid out one after another, and the satellite development and rocket launch modes have gradually transformed, and commercial space forces are expected to accelerate the layout process of low-orbit Internet. Recently, China Aerospace Science and Technology Corporation Commercial Satellite Co., Ltd. unveiled its design concept of Internet satellite for the first time, including standardization, low cost, integration, digitalization and scale. The company's production line in Tianjin has an annual production capacity of more than 100 satellites, and the satellite super factory in Wenchang, Hainan is expected to be put into operation in 2025, with an annual production capacity of 1,000 satellites. The third batch of networked satellites in Qian Fan (G60) constellation was successfully launched, and the number of satellites in orbit increased to 54. China Telecom invested 1 billion yuan to set up a new satellite company. Internationally, SpaceX has built the world's first low-orbit mobile phone direct connection constellation, and the three European aerospace giants Airbus Group, Terez Company and Leonardo Company want to jointly build a new satellite company.

Shengmei Shanghai: The plasma enhanced atomic layer deposition furnace tube equipment has passed the preliminary verification. Shengmei Semiconductor Equipment (Shanghai) Co., Ltd. announced in Guanwei today that its Ultra Fn A plasma enhanced atomic layer deposition furnace tube equipment (PEALD) launched in 2024 has passed the preliminary process verification of a semiconductor customer in Chinese mainland, and is undergoing the final optimization and preparing for mass production. Shengmei Shanghai also announced that its Ultra Fn A Thermal Atomic Layer Deposition Furnace Equipment (Thermal ALD) launched in 2022 has also successfully passed the process verification of another leading Chinese mainland customer, and its performance parameters are comparable to or even better than those of similar international competitors.NVIDIA's market value evaporated by 660 billion yuan overnight. On December 10th, local time, the three major US stock indexes collectively closed down, with the Dow down 0.35%, the Nasdaq down 0.25% and the S&P 500 index down 0.30%. Among them, NVIDIA fell by 2.69%, and its market value evaporated by 91.593 billion US dollars (about 664.047 billion yuan) overnight.During the year, there were 461 new indices, and the index investment fever continued to climb. On December 10th, in order to meet the investment demand of diversified indices, CSI Index Co., Ltd. officially released five new indices, including CSI 1000 Growth Index, CSI 1000 Value Index, CSI 2000 Growth Index, CSI 2000 Value Index and CSI 1000 Quality Balance Strategy Index. With the "listing" of the above five indexes, the number of newly-issued indexes reached 461 during the year, covering categories such as strategy, style, scale, industry, theme and other fixed-income indexes; Related index asset classes include stocks, fixed income, funds and futures. At the same time, the secondary market, this year, the heat of indexed investment is also high. Looking forward to the future, with the continuous vigorous growth of market demand and unabated heat, and the precise guidance and strong support from the supervisory level, the indexed investment ecology will become more and more perfect. (Securities Daily)